Vitamin B6

Vitamin B6

Vitamin B-6 (pyridoxine) is important for normal brain development and for keeping the nervous system and immune system healthy.

https://www.mayoclinic.org/drugs-supplements-vitamin-b6/art-20363468

Vitamin B6: a molecule for human health?

Vitamin B6 is an intriguing molecule that is involved in a wide range of metabolic, physiological and developmental processes. Based on its water solubility and high reactivity when phosphorylated, it is a suitable co-factor for many biochemical processes. Furthermore the vitamin is a potent antioxidant, rivaling carotenoids or tocopherols in its ability to quench reactive oxygen species. It is therefore not surprising that the vitamin is essential and unquestionably important for the cellular metabolism and well-being of all living organisms.

https://www.ncbi.nlm.nih.gov/pubmed/20110903

Magnesium

The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men. The role of nutritional status as key factor of successful aging is very well recognized. Among the different mechanisms by which nutrients may exert their beneficial effects is the modulation of the hormonal anabolic milieu, which is significantly reduced with aging. Undernutrition and anabolic hormonal deficiency frequently coexist in older individuals determining an increased risk of mobility impairment and other adverse outcomes. Mineral assessment has received attention as an important determinant of physical performance. In particular, there is evidence that magnesium exerts a positive influence on anabolic hormonal status, including Testosterone, in men.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958794/

The Interplay between Magnesium and Testosterone in Modulating Physical Function in Men

The role of nutritional status as key factor of successful aging is very well recognized. Among the different mechanisms by which nutrients may exert their beneficial effects is the modulation of the hormonal anabolic milieu, which is significantly reduced with aging. Undernutrition and anabolic hormonal deficiency frequently coexist in older individuals determining an increased risk of mobility impairment and other adverse outcomes. Mineral assessment has received attention as an important determinant of physical performance. In particular, there is evidence that magnesium exerts a positive influence on anabolic hormonal status, including Testosterone, in men.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958794/

Effects of magnesium supplementation on testosterone levels of athletes and sedentary subjects at rest and after exhaustion.

This study was performed to assess how 4 weeks of magnesium supplementation and exercise affect the free and total plasma testosterone levels of sportsmen practicing tae kwon do and sedentary controls at rest and after exhaustion. The testosterone levels were determined at four different periods: resting before supplementation, exhaustion before supplementation, resting after supplementation, and exhaustion after supplementation in three study groups, which are as follows: Group 1-sedentary controls supplemented with 10 mg magnesium per kilogram body weight. Group 2-tae kwon do athletes practicing 90-120 min/day supplemented with 10 mg magnesium per kilogram body weight. Group 3-tae kwon do athletes practicing 90-120 min/day receiving no magnesium supplements. The free plasma testosterone levels increased at exhaustion before and after supplementation compared to resting levels. Exercise also increased testosterone levels relative to sedentary subjects. Similar increases were observed for total testosterone. Our results show that supplementation with magnesium increases free and total testosterone values in sedentary and in athletes. The increases are higher in those who exercise than in sedentary individuals.

https://www.ncbi.nlm.nih.gov/pubmed/20352370

Zinc

Zinc status and serum testosterone levels of healthy adults.

Zinc deficiency is prevalent throughout the world, including the USA. Severe and moderate deficiency of zinc is associated with hypogonadism in men. However, the effect of marginal zinc deficiency on serum testosterone concentration is not known. We studied the relationship between cellular zinc concentrations and serum testosterone cross-sectionally in 40 normal men, 20 to 80 y of age. In four normal young men (27.5 +/- 0.5 y), we measured serum testosterone before and during marginal zinc deficiency induced by restricting dietary zinc intake. We also measured serum testosterone in nine elderly men (64 +/- 9 y) who were marginally zinc deficient before and after 3 to 6 mo of supplementation with 459 mumol/ d oral zinc administered as zinc gluconate. Serum testosterone concentrations were significantly correlated with cellular zinc concentrations in the cross-sectional study (lymphocyte zinc versus serum testosterone, r = 0.43, p = 0.006; granulocyte zinc versus serum testosterone, r = 0.30, p = 0.03). Dietary zinc restriction in normal young men was associated with a significant decrease in serum testosterone concentrations after 20 weeks of zinc restriction (baseline versus post-zinc restriction mean +/- SD, 39.9 +/- 7.1 versus 10.6 +/- 3.6 nmol/L, respectively; p = 0.005). Zinc supplementation of marginally zinc-deficient normal elderly men for six months resulted in an increase in serum testosterone from 8.3 +/- 6.3 to 16.0 +/- 4.4 nmol/L (p = 0.02). We conclude that zinc may play an important role in modulating serum testosterone levels in normal men.

https://www.ncbi.nlm.nih.gov/pubmed/8875519

Fenugreek

Beneficial effects of fenugreek glycoside supplementation in male subjects during resistance training: A randomized controlled pilot study.

Sixty healthy male subjects were randomized to ingest capsules of Fenu-FG (1 capsule of 300 mg, twice per day) or the matching placebo at a 1:1 ratio. The subjects participated in a supervised 4-day per week resistance-training program for 8 weeks. The outcome measurements were recorded at recruitment (baseline) and at the end of the treatment (8 weeks). The efficacy outcome included serum testosterone (total and free) levels, muscle strength and repetitions to failure, metabolic markers for anabolic activity (serum creatinine and blood urea nitrogen), and % body fat. The standard safety measurements such as adverse events monitoring, vital signs, hematology, biochemistry, and urinalysis were performed ... Fenu-FG supplementation showed beneficial effects in male subjects during resistance training without any clinical side effects.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6191980/

Can Fenugreek Boost Your Testosterone Levels?

Fenugreek has been researched for its potential to naturally increase testosterone. It contains compounds called furostanolic saponins, which are believed to increase testosterone production... The study found that testosterone levels increased by up to 46% in an impressive 90% of the participants.

https://www.healthline.com/nutrition/fenugreek-for-testosterone

Rhodiola Rosea

Rhodiola rosea L.: an herb with anti-stress, anti-aging, and immunostimulating properties for cancer chemoprevention

Rhodiola rosea L, a popular herb plant, is native to the high altitude regions of Asia, Europe and Northern Hemisphere. Rhodiola rosea extracts have a long history of use as an "Adaptogen" to non-specifically enhance the resistance of the body to both physical and emotional stresses for fighting fatigue and depression. Accumulating evidences have demonstrated that Rhodiola rosea extracts have strong anti-aging effects in different model organisms, such as fruit flies, worms, and yeast.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6208354/

Stress management and the role of Rhodiola rosea: a review.

Rhodiola rosea extract (RRE) fulfils important requirements. It is the main adaptogen approved by the HMPC/EMA for the indication 'stress' and influences the release of stress hormones while boosting energy metabolism as revealed in animal literature. RRE offers comprehensive treatment of stress symptoms and can prevent chronic stress and stress-related complications.

https://www.ncbi.nlm.nih.gov/pubmed/29325481

3,3'-Diindolylmethane

Multiple therapeutic and preventive effects of 3,3′-diindolylmethane on cancers including prostate cancer and high grade prostatic intraepithelial neoplasia

The male sex hormones, androgens mainly including testosterone and DHT, mediate their effects by binding to AR, forming androgen-receptor complex in cytoplasm and then translocating into the nucleus. The complex in the nucleus then binds to a DNA segment in androgen-responsive genes, the androgen response element, to regulate gene transcription. By turning the genes on or off, androgen and AR help direct the development of male sexual characteristics. In prostate cancer, androgen and AR are critical in oncogenesis and cancer growth. It has been shown in vitro and in vivo studies that DIM has an anti-androgen effect which downregulates AR and PSA. In androgen-dependent LNCaP cells, DIM suppresses cell proliferation, inhibits DHT stimulation of DNA synthesis and endogenous PSA transcription and suppresses androgen-induced AR translocation into the nucleus.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197384/

3,3'-Diindolylmethane suppresses high-fat diet-induced obesity through inhibiting adipogenesis of pre-adipocytes by targeting USP2 activity.

Indole-3-carbinol (I3C), a derivative abundant in cruciferous vegetables such as cabbage, is well known for its various health benefits such as chemo-preventive and anti-obesity effects. I3C is easily metabolized to 3,3'-diindolylmethane (DIM), a more stable form, in acidic conditions of the stomach. However, the anti-obesity effect of DIM has not been investigated clearly. We sought to investigate the effect of DIM on diet-induced obesity and to elucidate its underlying ... Our findings indicate that cruciferous vegetables, which can produce DIM as a metabolite, have the potential to prevent or treat chronic obesity mechanisms.

https://www.ncbi.nlm.nih.gov/pubmed/28586165

Eurycoma Longifolia

Review on a Traditional Herbal Medicine, Eurycoma longifolia Jack (Tongkat Ali): Its Traditional Uses, Chemistry, Evidence-Based Pharmacology and Toxicology

Longifolia Jack is reported to be rich in various classes of bioactive compounds such as quassinoids, canthin-6-one alkaloids, β-carboline alkaloids, triterpene tirucallane type, squalene derivatives and biphenyl neolignans, eurycolactone, laurycolactone, and eurycomalactone, and bioactive steroids. LC-MS is also recognized as a powerful tool for identification and quantification of various major and minor constituents from E. longifolia, which is used as a folk medicine for sexual dysfunction, aging, malaria, cancer, diabetes, anxiety, aches, constipation, exercise recovery, fever, increased energy, increased strength, leukemia, osteoporosis, stress, syphilis and glandular swelling; it is also used as an aphrodisiac, antibacterial, appetite stimulant and health supplement. It is suggested that the integration of natural chemistry, medicinal chemistry, biology, pharmacology, toxicology and other associated disciplines could be the most promising way to discovering drugs and to ensure a greater chance of advancing natural products and natural-based products into therapeutically useful drugs. E. longifolia is one of the most useful and safe traditional herbal medicines.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6274257/

Eurycoma Longifolia as a potential adoptogen of male sexual health: a systematic review on clinical studies.

Human clinical studies published between 2000 and 2014 were selected and thoroughly reviewed for relevant citations. Out of 150 articles, 11 met the inclusion criteria. The majority of articles included were randomized placebo-controlled trials, multiple cohort studies, or pilot trials. All these studies demonstrated considerable effects of EL on male sexual health disorders. Among them, 7 studies revealed remarkable association between the use of EL and the efficacy in the treatment of male sexual disorders, and remaining 4 studies failed to demonstrate sufficient effects on male sexual health. In summary, there is convincing evidence for the prominence of EL in improving the male sexual health. The review also substantiates the use of current methodology in the development of novel and more rationale natural herbal medicines for the management of male sexual disorders.

https://www.ncbi.nlm.nih.gov/pubmed/28259255

Piperine

Black pepper and health claims: a comprehensive treatise.

The key alkaloid components of Piper Nigrum, that is, piperine assist in cognitive brain functioning, boost nutrient's absorption and improve gastrointestinal functionality. In this comprehensive treatise, efforts are made to elucidate the antioxidant, antimicrobial, anti-inflammatory, gastro-protective, and antidepressant activities of black pepper.

https://www.ncbi.nlm.nih.gov/pubmed/23768180

Piper nigrum and piperine: an update

Based on modern cell, animal, and human studies, piperine has been found to have immunomodulatory, anti-oxidant, anti-asthmatic, anti-carcinogenic, anti-inflammatory, anti-ulcer, and anti-amoebic properties.

https://www.ncbi.nlm.nih.gov/pubmed/23625885

Piper Nigrum Extract

Black pepper and health claims: a comprehensive treatise

Black pepper (Piper Nigrum L.) is an important healthy food owing to its antioxidant, antimicrobial potential and gastro-protective modules. Black pepper, with piperine as an active ingredient, holds rich phytochemistry that also includes volatile oil, oleoresins, and alkaloids. More recently, cell-culture studies and animal modeling predicted the role of black pepper against number of maladies. The free-radical scavenging activity of black pepper and its active ingredients might be helpful in chemoprevention and controlling progression of tumor growth.

https://www.ncbi.nlm.nih.gov/pubmed/23768180

Piper nigrum and piperine: an update

Black pepper (Piper nigrum L.) is a very widely used spice, known for its pungent constituent piperine. However, in addition to its culinary uses, pepper has important medicinal and preservative properties, and, more recently, piperine has been shown to have fundamental effects on p-glycoprotein and many enzyme systems, leading to biotransformative effects including chemoprevention, detoxification, and enhancement of the absorption and bioavailability of herbal and conventional drugs.

https://www.ncbi.nlm.nih.gov/pubmed/23625885